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Veterinary - Publications

This site contains scientific and medical studies that have benefitted from our products.

Veterinary

Cats

Paltinieri S et al. (2018) Diagnostic performances of manual and automated reticulocyte parameters in anaemic cats. Journal of Feline Medicine and Surgery; 20(2): 122
What we see as the essence: Reticulocyte percentage (Ret%), reticulocyte number (Ret#) and reticulocyte production index(RPI) may be used to differentiate regenerative anaemia (RA) from non-regenerative anaemia (NRA) in cats.

Cook A et al. (2016) Quality requirements for veterinary hematology analyzers in small animals-a survey about veterinary experts' requirements and objective evaluation of analyzer performance based on a meta-analysis of method validation studies: bench top hematology analyzer.
Vet Clin Pathol; 45(3): 466
What we see as the essence: Total allowable error (TEa) is determined for haematological parameters for dogs and cats based on experts survey. Using published data the authors conclude that XT-2000iV, ADVIA 2120 and Cell-Dyn 3500 fulfilled experts requirements. Despite known difficulties of both methods, manual and analyser, in identifying monocytes the authors point out here that medical relevant monocytoses were detected.

Riond B et al. (2015) Effective prevention of pseudothrombocytopenia in feline blood samples with the prostaglandin I2 analogue Iloprost. BMC Vet Res.; 11:183
What we see as the essence: The study showed an anti-aggregatory effect of Iloprost in feline blood. In all clinically healthy cats investigated, pseudothrombocytopenia was prevented by adding Iloprost to EDTA tubes prior to blood collection.

Granat F et al. (2014) Feline reference intervals for the Sysmex XT-2000iV and the ProCyte DX haematology analysers in EDTA and CTAD blood specimens. J Feline Med Surg;16(6):473
What we see as the essence: Reference intervals (RI) were established for cats using XT-2000iV and Procyte. This RI can be directly applied in veterinary laboratories using these analysers.
CTAD is a better option than EDTA for feline blood samples.

Bauer N et al. (2012) Evaluation of the automated hematology analyzer Sysmex XT-2000iV ™ compared to the ADVIA ® 2120 for its use in dogs, cats, and horses. Part II: Accuracy of leukocyte differential and reticulocyte count, impact of anticoagulant and sample aging. J Vet Diagn Invest. 24(1):74
What we see as the essence: The overall performance of the Sysmex XT-2000iV was excellent and compared favourably with that of the ADVIA 2120 as well as manual count.

Weissenbacher S et al. (2011) Evaluation of a novel haematology analyser for use with feline blood. Vet J 187(3):381
What we see as the essence: The XT-2000iV is suitable for use with feline blood. Sysmex overcomes the problem of size-overlapping between RBC and PLT with the PLT-O which has a fairly good correlation to the manual count.

Dogs

Fuchs J et al. (2017) Canine reticulocyte hemoglobin content (RET-He) in different types of iron-deficient erythropoiesis. Vet Clin Pathol 46(3):422
What we see as the essence: Based on the study results the authors propose that RET-He can be considered as an early indicator of iron deficiency.

Cook A et al. (2016) Quality requirements for veterinary hematology analyzers in small animals-a survey about veterinary experts' requirements and objective evaluation of analyzer performance based on a meta-analysis of method validation studies: bench top hematology analyzer.
Vet Clin Pathol; 45(3): 466
What we see as the essence: Total allowable error (TEa) is determined for haematological parameters for dogs and cats based on experts survey. Using published data the authors conclude that XT-2000iV, ADVIA 2120 and Cell-Dyn 3500 fulfilled experts requirements. Despite known difficulties of both methods, manual and analyser, in identifying monocytes the authors point out here that medical relevant monocytoses were detected.

Piane L et al. (2016) Spurious reticulocyte profiles in dogs with large form babesiosis: a retrospective study. Vet Clin Pathol. 45(4): 598
What we see as the essence: Abnormal reticulocyte scattergrams may occur in dogs with babesiosis and alert clinical pathologist to consider diagnosis.

Lee JM et al. (2016) Changes of hematological reference depends on storage period and temperature conditions. Lab Anim Res. 32(4): 24
What we see as the essence: When measuring haematological samples of dogs and rats, it will be
necessary to analyse fresh blood since PLT and WBC showed high variation with time and
temperature. Good agreement and correlation between Advia 2120i and XN-V for CBC parameters and WBC subpopulations were found.

Bourges-Abella NH (2014) Changes in hematology measurements in healthy and diseased dog blood stored at room temperature for 24 and 48 hours using the XT-2000iV analyser. Vet Clin Pathol; 43(1):24
What we see as the essence: "Delayed analysis of canine blood stored at room temperature and measured by the XT-2000iV was accompanied by moderate variations in certain haematologic variables (MCV, HCT, MCHC, PLT, RET#, RET%, MONO#).”

Bauer N et al. (2012) Evaluation of the automated hematology analyzer Sysmex XT-2000iV ™ compared to the ADVIA ® 2120 for its use in dogs, cats, and horses. Part II: Accuracy of leukocyte differential and reticulocyte count, impact of anticoagulant and sample aging. J Vet Diagn Invest. 24(1):74
What we see as the essence: The overall performance of the Sysmex XT-2000iV was excellent and compared favourably with that of the ADVIA 2120 as well as manual count.

Bourges-Abella NH et al. (2011) Canine reference intervals for the Sysmex XT-2000iV hematology analyzer. Vet Clin Pathol. 40(3):303
What we see as the essence: Reference intervals for haematologic analytes and indices were determined under controlled conditions for a well characterised population of dogs following international recommendations. These reference interval can be adopted by laboratories using similar equipment and canine patient population.

Gelain ME et al. (2010) Identification of neoplastic cells in blood using the Sysmex XT-2000iV: a preliminary step in the diagnosis of canine leukemia. Vet Clin Pathol 39(2):169
What we see as the essence: The creation of a 'leukaemic flag' consisting of increased WBC count, a high fluorescence area gate and a lysis resistant region provides an automated, reliable and rapid tool for preliminary investigation of dogs with suspected leukaemia. The flag is objective and has high specificity which can be further increased by scattergram evaluation.

Mathers RA et al. (2008) Evaluation of the Sysmex XT-2000iV haematology analyser for rat, dog and mouse whole blood samples. Comp Clin Pathol 17: 137
What we see as the essence: The XT-2000iV analyser proved to be reliable with satisfactory performance for analysing rat, dog and mouse blood samples. The analyser was robust and dependable with no breakdowns or software problem encountered in this pharmaceutical lab setting.

Horses

Bauer N et al. (2012) Evaluation of the automated hematology analyzer Sysmex XT-2000iV ™ compared to the ADVIA ® 2120 for its use in dogs, cats, and horses. Part II: Accuracy of leukocyte differential and reticulocyte count, impact of anticoagulant and sample aging. J Vet Diagn Invest. 24(1):74
What we see as the essence: The overall performance of the Sysmex XT-2000iV was excellent and compared favourably with that of the ADVIA 2120 as well as manual count.

Mice/Rats

Lee JM et al. (2016) Changes of hematological reference depends on storage period and temperature conditions. Lab Anim Res. 32(4): 24
What we see as the essence: When measuring haematological samples of dogs and rats, it will be
necessary to analyse fresh blood since PLT and WBC showed high variation with time and
temperature. Good agreement and correlation between Advia 2120i and XN-V for CBC parameters and WBC subpopulations were found.

White JR et al. (2016) Evaluation of hematologic variables in newborn C57/BL6 mice up to day 35. Vet Clin Pathol 45(1):87
What we see as the essence: Reference intervals (RI) were established for newborn mice of C57/BL6 strain, which is commonly used for research in disease models.

Moorhead KA et al. (2016) Alterations due to dilution and anticoagulant effects in hematologic analysis of rodent blood samples on the Sysmex XT-2000iV. Vet Clin Pathol.; 45(2):215
What we see as the essence: Several variables, most notably platelet count, differ based on the anticoagulant used thus the values from heparinized vs EDTA-anticoagulated samples should not be directly compared. Dilution has effect on MCV and MCHC.

Criswell KA et al. (2014) Comparison of the Sysmex XT-2000iV and microscopic bone marrow differential counts in Wistar rats treated with cyclophosphamide, erythropoietin, or serial phlebotomy.. Vet Clin Pathol 46(3):422
What we see as the essence: The Sysmex XT-2000iV provides quantitative bone marrow differential counts in rats treated with cyclophosphamide, erythropoietin, or serial phlebotomy. Analyser results were comparable to microscopic differential counts.

Mathers RA et al. (2008) Evaluation of the Sysmex XT-2000iV haematology analyser for rat, dog and mouse whole blood samples. Comp Clin Pathol 17: 137
What we see as the essence: The XT-2000iV analyser proved to be reliable with satisfactory performance for analysing rat, dog and mouse blood samples. The analyser was robust and dependable with no breakdowns or software problem encountered in this pharmaceutical lab setting.

Others

Herman N et al. (2018) Hematology reference intervals for adult cows in France using the Sysmex XT-2000iV analyzer, J Vet Diagn Invest.; 30(5): 678
What we see as the essence: Reference intervals (RI) were established for cattle using XT-2000iV. These RI can be used in veterinary laboratories after validation if the cattle population is different.

Burden FA et al. (2016) Reference intervals for biochemical and haematological parameters in mature domestic donkeys (Equus asinus) in the UK. Equine Veterinary Education; 28(3): 134
Free online
What we see as the essence: The authors define reference intervals for haematological and biochemical parameters in mature domestic donkeys.

General

Natibi M et al. (2018) ASVCP guidelines: Allowable total error hematology. VET Clin Pathol; 47:9
Free online
What we see as the essence: Recommendations discussing how to perform evaluation of haematological measurements. Definition of Total allowable error (TEa) for the most common analysed haematological parameters are defined.

Sysmex Literature List - Veterinary

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