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Diagnostic Perspectives

Diagnostic Perspectives will publish original research articles, reviews, editorials and opinion papers in the field of clinical laboratory diagnostics, including themes such as disease / therapy monitoring and patient management.

To make information available in a timely manner, new articles will be added as soon as they are available. For this reason - and for the sake of the trees in this world - a printed version of Diagnostic Perspectives does not exist. For the sake of convenience all articles are available with open access for direct download without pre-registration.

Impressions of the IFCC Worldlab 2011 in Berlin – Launch of the new XN series by Sysmex Emergency myocardial infarction — the live-saving discovery of a hidden leukaemia Optimisation of the quality of the results and the turn-around times in the laboratory Early detection of essential thrombocythaemia reduces the risk of stroke in a clinic patient SEED: Overview of the benefits of switching from a 3-part differential to a 5-part differential haematology analyser SEED: The red blood cell indices SEED: The role of the peripheral blood smear in the modern haematology laboratory. SEED: The use of absolute figures in haematology Lymphocyte Follicular lymphoma Atypical lymphocyte Prolymphocytes and lymphocytes Modified morphology of cells Blood film contaminated by saliva Bacterial aggregates on blood film Streptococcal septicaemia Epithelial cells Clostridium perfringens Auto-immune haemolytic anaemia (AIHA) Red blood cells Red blood cells Pseudo-fragmentocytes Fragmented red blood cells and thrombocytopenia Red blood cells and lymphocyte Acanthocytes Echinocytes Echinocytes Acanthocytes Howell-Jolly bodies Howell-Jolly body Howell-Jolly body Red blood cell with basophilic stippling and polychromatic red blood cell HbH cell 'Rouleaux formation' 'Rouleaux formation' and clumping Edge of blood film Disturbed cell distribution Frozen blood sample Granulocyte Degraded granulocytes Granulocytes of a patient treated with GCS-F Band cells Pseudo-Pelger's nuclear anomalies Pollen in blood film Schizont of plasmodium malariae Giant platelet Platelet on top of red blood cell Plasmodium falciparum Mucous membrane epithelial cell Drop of saliva Breast carcinoma cells on blood film Endothelial cells on blood film Malignant melanoma cells on blood film Blood film with staining artefact Striations with a blue cast on blood film Flocculated cryoglobulins Blood film with striations with a blue cast Extreme haemolysis Abnormal platelets Platelets Anisocytosis of platelets Accumulation of platelets on granulocytes Thrombocytosis, anisocytosis of platelets and giant platelets Hairy cell leukaemia-variant Cytoplasmic protrusions of a lymphocyte Cytoplasmic fragments split off a blast Hairy lymphocyte Hairy cell leukaemia Acute haemolysis Blood sample reflecting acute intravascular haemolysis Auto-immune haemolytic anaemia Agglutinated red blood cells and marked polychromasia Schistocytes and thrombocytopenia Leucoerythroblastic condition and schistocytes Colorectal carcinoma cells in bone marrow T-cell large granular lymphocytic (LGL) leukaemia Severe aplastic anaemia Acute T lymphoblastic leukaemia (T-ALL) Chronic myelogenous leukaemia (CML) Chronic lymphocytic leukaemia / prolymphocytic leukaemia Acute myeloid leukaemia (AML-M4) Platelet aggregates Thrombocytopenia and platelet anisocytosis Platelet satellitosis Thrombocytopenia and detection of cytoplasm fragments from monoblasts Iron deficiency anaemia Erythrocytosis Severe aplastic anaemia Tumour cells from malignant melanoma Breast cancer cells Bone marrow analysis of a breast cancer patient B-ALL / Burkitt lymphoma Auer rods in cytoplasm of myeloblasts Cortical T-ALL Streptococci in blood film Incidental detection of Borrelia recurrentis Atypical promyelocyte in peripheral blood Diagnosis of AML in bone marrow Typical blasts in AML-M3v Extreme thrombocytosis in chronic myelogenous leukaemia Flocculated cryoglobulin in phase contrast microscopy image Thrombocytosis and platelet anisocytosis Gametocyte Thick blood film with high density of malaria pathogens Throphozoites with malaria tropica Malaria parasite Primary myelofibrosis (PMF) Primary myelofibrosis (PMF) in prefibrotic stage Bone marrow histology showing prefibrotic stage of PMF Primary myelofibrosis (PMF) in fibrotic stage Primary myelofibrosis (PMF) in bone marrow histology Peripheral blood of a patient with breast cancer and bone metastases Bone marrow cytology showing many tumour cells of breast cancer Infiltration of bone marrow by a lobular carcinoma of the breast Infiltration of bone marrow by a lobular carcinoma of the breast Bone marrow histology of a patient with breast cancer Peripheral blood showing a typical B-CLL B-CLL with granulocytopenia Chronic lymphocytic leukaemia / prolymphocytic leukaemia Peripheral blood of a patient with B-CLL Dense infiltration of bone marrow by B-CLL Acute myeloid leukaemia (AML) Blast cells in peripheral blood Blasts in bone marrow cytology Bone marrow histology with blast cells Bone marrow histology showing blasts Giant platelets in peripheral blood Peripheral blood of a patient with ET showing an isolated thrombocytosis Peripheral blood of a patient with CML Exceptionally large megakaryocytes Abundant and atypical megakaryocytes Bone marrow histology of a patient with severe aplastic anaemia Peripheral blood of a patient showing isolated neutropenia Isolated congenital reduction of erythropoiesis in bone marrow Pancytopenia (tricytopenia) in peripheral blood Bone marrow cytology of a patient with aplastic anaemia Peripheral blood of a patient with CML Peripheral blood of a patient with CML Bone marrow cytology of a patient with CML High number of megakaryocytes BCR-ABL fusion gene detected by fluorescence-in-situ-hybridisation Hodgkin cells Hodgkin's lymphoma Gaucher cells Bone marrow histology of a patient with sarcoidosis Bone marrow cytology showing predominantly ringed sideroblasts Peripheral blood of a patient with MDS Bone marrow histology showing altered bone marrow architecture and pronounced dysplasia Macrocytic, hyporegenerative anaemia Bone marrow cytology showing dysplastic changes in all cell lineages Bone marrow cytology of a patient with multiple myeloma 'Rouleaux formation' of red blood cells 'Rouleaux formation' in blood of a patient with chronic polyarthritis Bone marrow cytology of a patient with CMML Plasma cells in bone marrow of a patient with multiple myeloma Iron accumulation in bone marrow Increase of all three cell lineages in peripheral blood of a patient with PV Blood film of a patient with polycythaemia vera (PV) Bone marrow histology with an increased number of megakaryocytes Lymphoma cells in peripheral blood Mantle cell lymphoma infiltrating bone marrow Hairy cell leukaemia Bone marrow cytology of a patient with immunocytoma Bone marrow infiltrated by a diffuse large B-cell lymphoma Normal bone marrow cytology Normal bone marrow cytology Indications for bone marrow examination and decision criteria for bone marrow cytology or bone marrow histology Classification of Neutrophilic Granulocytes SEED: A closer look at protein detection in microscopic urinalysis SEED: APTT, Heparin and its mechanism of action SEED: Chronic Pyelonephritis SEED: Coagulation emergencies - understanding why turnaround times are vital SEED: CSF – a material with special requirements SEED: Haemophilia – a laboratory diagnostic approach SEED: Laboratory investigation of haematuria SEED: Preanalytical aspects in urinalysis SEED: Preanalytical influences on coagulation test results SEED: Principles of haemostasis SEED: Prothrombin Time Test SEED: Quality control in coagulation testing SEED: The role of the D-dimer test in clinical diagnostics UX-2000 – Urinalysis analyser product video XP-300 – Haematology analyser The 5 Principles of Silent Design CA-101 & CA-104 Haemostasis analyser CS-5100 Haemostasis System - Video The immature platelet fraction (IPF) in neonates Usefulness of NEUT-X determination in routine diagnostic procedures: application to myelodysplastic syndromes Pekelharing Diag Persp Vol1 1-11 Fighting for fair competition: blood doping – a persistent challenge and smart approaches to detect it Platelet morphology and IPF during treatment with haemodialysis Impulses from routine analysis – suspected HUS 3rd European OSNA User Club focuses on scientific projects Acute promyelocytic leukaemia - the diagnostic pathway illustrated by an emergency patient case XS-Series – Outstanding X-Class technology Impressions from the Sysmex European Haematology Symposium 2013 in Lyon Counting of highly fluorescent lymphocytes (HFLC) as antibody-producing plasma cells on XE-5000 Examples of body fluid analysis with the XE-5000 The immature platelet fraction (IPF) - The first to know about megakaryocyte activity Quantitative and qualitative monitoring of erythropoiesis with RET-He even on XE-2100 and XT-2000i The clinical relevance of measuring NRBC in the XN-CBC The Immature Granulocyte Count - The first to know about inflammation The 'second generation' urine Fluoresence Flow Cytometry: the key to modern screening for urinary tract infections Sysmex UF-1000i and UF-500i: the modern age of urinalysis XE-5000 Case Manager - combining laboratory information with clinical knowledge XS-Series - Ideal for paediatric blood analysis XS-Series - Sysmex 5-part differential haematology analyser with fluorescence technology for small workloads XT 4000i Pushing limits in routine lab haematology Auer rods 1 Auer rods 2 Cabot rings Doehle bodies 1 Doehle bodies 2 Gigant PLT Granulated myeloblast 1 Granulated myeloblast 2 Sézary cells Hairy cells Howell-Jolly-bodies 1 Malaria tropica May-Hegglin anonaly Mononucleosis Platelet satellitosis Platelet satellitosis 1 Joachim Linssen - Director Medical Scientific Departement Matthias Kutzner - Vice President Reagent Production Mirko Müller - Assistant Director Supply Chain Management SEED: The new oral anticoagulant drugs - what influence do they have on routine coagulation testing SEED: The Thrombin Time Test and Reptilase Test – what is their role in coagulation testing? BEAMing Digital PCR IFCC World Lab Istanbul 2014 Blood Film Master Advanced UF-Series Blood Film Master Sienna+ tracer - size does matter! Sysmex against Cancer Sysmex Arab Health 2015 - Video Atypical lymphocytes suspected reactive Band cell Basophil Blast Cell Eosinophil Hairy cell Lymphocyte Metamyelocyte Monocyte Myeloblast Myelocyte Nucleated Red Blood Cell Plasma cell Prolymphocyte Promonocyte Promyelocyte Segmented neutrophil A new clinical cut-off of cytokeratin 19 m RNA copy number in sentinel lymph node of breast cancer Does Lobular Histology matter in the era of sentinel node biopsy and OSNA Intraoperative predictive model for non-SLN metastasis using Total Tumor Load assessed by OSNA OSNA in the prediction of axillary status in breast cancer patients Possible intra-operative implications Preoperative identification of early breast cancer patients for safely avoiding axillary surgery The new predicting score of axillary lymph node metastases in breast cancer patients How to avoid unnecessary SLNB in patients with DCIS Sysmex against Cancer SEED: Medical statistics – your support when interpreting results SEED: Reference ranges and what Sysmex can offer White Paper: Flow cytometry for the analysis of microorganisms White Paper Cytometry White Paper Cytométrie SEED: Laboratory investigation of haemolysis CS-1600 Haemostasis System SEED: SNCS IQAS Online – the quality control solution for the haematology laboratory SEED: The importance of reticulocyte detection Assessing platelet function-a basic introduction SEED: Lymphocyte differentiation update – helpful or dispensable? SEED: Malaria – the global burden Sysmex Symposium The Art of Particles SEED: Pre-analytics create the correct preconditionsto achieve high-quality analysis results part II SEED: Pre-analytics create the correct preconditions to achieve high-quality analysis results part I Sysmex QC material preparation SEED: Challenges in monocyte counting International Symposium Paris Feb 2016 Synopsis III SEED: Platelet detection and the importance of a reliable count SEED: The importance of thrombocytopenia and its causes SEED: Haematopoietic Stem Cell Transplantation - Part I SEED: Haematopoietic Stem Cell Transplantation - Part II SEED: Blast cells – a diagnostic heavyweight Apoptosis Sequence Immuno Sequence My Way Selfies - German version Sysmex and CRC Screening: a Perfect FIT Sentifit 270 SEED: The ‘erythrocyte sedimentation rate’: a well-timed indicator of clinical value My Way selfies White Paper: Managing stem cell apheresis effectively White Paper: Managing haematopoietic stem cell transplantation pre- and post-apheresis White Paper: Differential diagnosis of thrombocytopenia White Paper: Identifying poor antiplatelet drug response and its risks early on White Paper: Importance of the immature platelet count for effectively managing immune thrombocytopenia ITP treatment Stronger Together against Cancer White Paper: Characterisation reactive conditions White Paper: White blood cell functionality Citometria a flusso per l'analisi di microrganismi (lieviti, batteri, ecc.) SEED: Quality control materials: the better you treat them, the more you can trust your haematology results Sysmex CyFlow Animation SEED: Synovial fluid - part 1 main characteristics SEED: Haematology - Biomedical Validation SEED: Traceability and measurement uncertainty SEG NMS Certificate ISO 14001 2015 valid until 26 04 2020 SEG NMS Zertifikat ISO 14001 2015 gueltig bis 26 04 2020 Magseed White Paper: Can OSNA CK19 copy number predict nodal status when axillary dissection is not performed? Sysmex Brochure OSNA EN Learn more about Carmen and the value of the blood based OncoBEAM RAS CRC test Sentimag Brochure Pennys story - Optimised treatment in breast cancer Onco BEAM EGFR Kit (RUO) OncoBEAM RAS CRC Platform BEAMing Digital PCR Technology Application Note: Plant aneuploidy using flow cytometry XN-1500 video Environmentally advanced. The Sysmex production plant SEED: Internal quality control in haematology – for the sake of the patient Pannoramic 1000 Flash IV White Paper RXT: OSNA – fine-tune your radiation therapy with more differentiated information Sysmex-academy.com fr Sentimag Sienna Brochure TR P-1000 Brochure EN Pannoramic 1000 animation SEG NMS Certificate EN ISO 13485 2016 valid until 26 05 2021 SEG NMS Zertifikat EN ISO 13485 2016 gueltig bis 26 05 2021 CS-2400/2500 SEED: Looking deeper into inflammatory conditions from a laboratory and clinical perspective FIT for colorectal cancer (CRC) screening Incorporation of OncoBEAM RAS liquid biopsy into clinical practice Sysmex Academy Online Join live webinars Lab Manager EN Sysmex Academy Online Sysmex Brand Movie Sysmex History SEG ISO-Zertifikat ISO 14001 2015 DE gueltig bis 24-07-2020 SEG ISO-Certificate ISO 14001 2015 EN valid until 24-07-2020 Sysmex is starting a new journey FOB Gold Folder EN FIT Tube Procedure EN Pannoramic DESK Video Pannoramic 1000 Video Pannoramic Scan Video Incorporation of Onco BEAM RAS liqued biopsy into clinical practice White Paper: OSNA - Enhancing the power of nodal staging SEG ISO-Certificate 13485 EN exp 2022-05-16 SEG ISO-Zertifikat 13485 DE gueltig bis 2022-05-16 White paper: Going beyond the visible Radiologist Dr El Bejjani Surgeon Dr Alran XN-L Series Workflow of OSNA RD-210 SEED: Haemophilia SEED: Synovial fluid – part 2 laboratory evaluation SEED: Body fluid cell counts – how to perform and interpret the results

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