The judgment of an abnormal blood smear is an art. Therefore, a well-made blood smear is essential for optimal microscopy examination of the blood cell differential.

Nowadays, morphology experts are not alone. Powerful tools exist to support them in preventing errors and inconsistencies common with manual blood smear preparation and interpretation.

We are passionate about the beauty of well-prepared blood smears and the clinical insights that can be discovered from cell morphology.

The Sysmex Smear Workflow is a unique concept that optimises the preparation of peripheral blood smears for automated digital morphology. Increase productivity and quality, all while minimising contact with biohazardous material.

A good quality smear, thorough examination and proper interpretation in line with the patient's clinical state should be ensured by the haematology pathologist. With the Sysmex Smear Workflow, we make this possible.

ecosight™: The green way of blood smear preparation for high workloads

Have you been cautious until now to switch your smear preparation workflow to a more environmentally friendly and sustainable variant, fearing a disruption to your established workflow and/or negative reactions due to a change in quality of the morphology images? This is well understandable.

Now, it’s safe to make this move. With the ecosight™ smear workflow, you can experience all the advantages of methanol-free working without noticing any difference in your workflow. In fact, it’s an effortless transition altogether. Preparation for the change is minimal, and there won’t be any loss in quality of your cell morphology images – you may even notice a slight improvement, so cell judgement won’t be impaired by the new procedure.

The MCDh Zero methanol-free staining is a large plus for the working environment. Blast cells have a very characteristic cytoplasm and nuclear staining which makes them easier to distinguish in the MCDh Zero-staining than in the MGG staining.

University Hospital Odense, Denmark

ecosight™ helps you take the ‘m’ out of methanol: it’s ethanol from now on

With MCDh Zero, the ethanol-based staining reagents used in our ecosight™ concept, you will achieve a greener smear workflow and cell morphology analysis – without compromising on staining quality and cell morphology appearance.

Developed by the renowned RAL Diagnostics, and carefully tested and validated by Sysmex and CellaVision on the SP-50 and DI-60, we can assure staining results are consistent with conventional staining protocols, but also with smear workflow results in smaller labs, where methanol-free MCDh reagents were successfully introduced several years ago. This means you can finally align all cell morphology procedures and their level of sustainability across all of your lab sites.

Blood smear preparation for smaller workloads

The Sysmex Smear Workflow for smaller laboratories comprises the HemaPrep^® and RAL StainBox with methanol-free reagents, combined with the CellaVision^® DC-1. The concept seamlessly covers the whole haematology workflow so that you can provide results with consistently high quality.

ecosight™

ecosight™: Zero methanol. 100% quality.

ecosight™ is the green smear workflow for high-throughput environments. It comprises the automated slide preparation unit SP-50, the digital imaging analyser DI-60, and the set of four methanol-free, Romanowsky-derived reagent components of MCDh Zero for pre-fixation, staining, buffering and rinsing.

The ecosight™ smear workflow components can be integrated into the haematology workstations XR-1500 and XR-3000, and the automation line XR-9000. They may also be operated stand-alone.

Transition from conventional to ecosight™ workflows requires only new spout kits and a software update. That’s all.

Benefits at a glance:

Reduce toxic exposure and create a safer workplace
Simplify safety infrastructure incl. storage conditions
Eliminate methanol recovery procedures
Cut down on operational costs
Support environmental policies and sustainability goals
Maintain quality and consistency of staining results and pattern recognition
Uniquely designed for SP-50
Unify your procedures: align your core lab with methanol-free workflows present in your satellite labs

MCDh reagents

MCDh reagents – bringing cells to life

Benefits at a glance:

no fume cupboard required
no reagent preparation needed: ready-to-use at your convenience
open stability of 28 days
standard and user-defined staining protocols
adapted protocol for staining bone marrow slides

The methanol-free Micro Chromatic Detection for haematology (MCDh) reagents apply a panoptic staining method similar to the classic May-Grünwald-Giemsa/Wright stains for blood smears but have added benefits.

Thanks to the exceptional appearance of the cells, you will save time and feel confident that no details will be missed during morphological analysis, as well as the fact that results will be comparable and reproducible.

For high-workload smear workflows using the SP-50 and DI-60, we offer a methanol-free variant with ecosight™. More information can be found right here on this page, under the ‘ecosight™’ tab.

HemaPrep®

HemaPrep® – it all starts with a good smear

Benefits at a glance:

Produce high-quality blood smears – only little experience needed
Control smear length with the variable slide-making speed
Portable device
No power source needed
Packaging includes two extra spreader blades

The HemaPrep^® is a small mechanical, semi-automated device for the standardised preparation of up to two peripheral blood smears at a time.

The HemaPrep^® makes producing consistently high-quality blood smears easy. With just a single action, the semi-automatic slider distributes the cells evenly on the smear. The standardised and high-quality appearance of the cells helps improve morphological assessment. Both the length and thickness of the blood smear can be adjusted by changing the speed of the smear preparation step.

Using the HemaPrep^®, also less experienced technicians can produce blood smears in a reproducible manner. The variability in smear quality between operators is reduced, which ensures reproducible results, particularly if a standardised staining process follows the slide preparation step.

RAL StainBox

RAL StainBox – staining made easy

RAL StainBox benefits at a glance:

staining phases are monitored
minimal routine maintenance
out-of-the-box, methanol-free reagents
RFID (radio frequency identification) technology for storing reagent traceability data

A skilfully stained slide is a crucial step in the smear workflow and is a delicate process. The semi-automated RAL StainBox is easy to use and produces the optimal staining result for your peripheral blood or bone marrow smears. The staining procedure is standardised through a software-controlled process, thereby giving your morphology assessments a uniform basis.

It is also optional to substitute the RAL StainBox with the RAL Stainer.

CellaVision® DC-1

CellaVision® DC-1 – great things come in small packages

CellaVision® DC-1 benefits at a glance:

automated blood cell differentials promote high efficiency
enhanced quality of results from consistency and standardisation
connectivity that facilitates remote collaboration and validation of results
high-quality images highlight all cellular details
smoother workflow and data management in the haematology laboratory
accelerated turnaround time to clinical diagnosis ultimately benefits the patient
valuable education tool for laboratory staff aided by the reference cell library and side by side blood cell images

Digital cell morphology and network integration are trends in laboratories today. The CellaVision® DC-1 is the latest in a line of proven automated digital cell morphology devices and is tailor-made for smaller and satellite laboratories.

The DC-1 consists of an automated microscope, a high-quality digital camera and an advanced computer system that uses artificial neural network (ANN) technology to locate, capture and pre-classify white blood cells from a stained blood smear. The system also pre-characterises the red blood cell morphology and provides a functionality for performing platelet estimates. ANNs are very good in pattern recognition and classification because of their ability to generalise and make decisions. The CellaVision® DC-1 (and Sysmex DI-60) uses ANNs that have been trained on thousands of cell images. Over 300 different features, e.g. shape, colour, size and nuclear to cytoplasmic ratio, have been identified for each cell and are used in determining the cell’s classification into one of 17 cell classes.

WBC, RBC and PLT images are stored, together with differential results, in a database. Captured cell images can be reviewed and compared in multiple cell galleries or magnified and studied in detail individually. After reclassification and validation, the results are sent to the Sysmex Extended IPU or LIS system. Additionally, there is a cell reference library which not only benefits everyday laboratory work, but also allows for educational opportunities.

This technology can dramatically improve the quality and efficiency of the historically subjective differential review. Advances in image analysis and network integration allow the cell image to finally become a fundamental part of the patient’s record.

Bone marrow morphology

Bone marrow morphology workflow: Core insights from aspirates supporting confident clinical decisions

With the CellaVision® Bone Marrow Aspirate (BMA) Application as the core component, Sysmex offers a morphology workflow dedicated to the analysis of bone marrow aspirates.

The application developed by CellaVision runs on the CellaVision® DC-1 digital morphology analyser. It is complemented by a staining device – for example the RAL StainBox using the dedicated Kit RAL StainBox BBM methanol-free reagents – and optional software components (CellaVision^® BMA Server and BMA Review Software) for central data storage and remote review capabilities.

This fully integrated solution has been designed to automate, standardise, and digitise bone marrow morphology workflows. It reduces manual effort, improves diagnostic confidence, and supports remote collaboration.

Benefits at a glance:

Streamlines and digitises bone marrow workflows with AI-assisted pre-classification – for better workflow efficiency
Reduces tedious manual tasks such as staining, locating, counting, and classifying cells
Offers multiple automation levels to support different case complexities
Provides a more ergonomic working environment than manual microscopy
Promotes standardisation and diagnostic confidence through an intuitive digital environment created by CellaVision and Sysmex
Limits variation through consistent procedures, e.g. standardised area selection
Promotes accuracy with side-by-side comparisons and reference cell images
Improves traceability with digital images and compiled differential results
Fosters collaboration, knowledge-sharing and decision-making between colleagues with remote review and verification support across locations
Elevates bone marrow morphology expertise by strengthening proficiency and competency development

Learn how the CellaVision^® Bone Marrow Aspirate Application can support consistent review, efficient workflows, and collaborative diagnostics by visiting the dedicated product page.