The Nexus IB10 Analyzer is a point-of-care (POC) solution for near-patient testing to provide accurate diagnostics of critically ill patients in acute and critical care settings. This analyser is a valuable addition to intensive care units (ICU), emergency departments (ED), and other near-patient testing settings, enabling clinicians to perform a wide range of commonly used whole blood or plasma tests, together with innovative biomarkers for the diagnosis, prognosis, and monitoring of acute and critical medical conditions.

Rapid point-of-care testing technology

POC testing significantly reduces the time that passes between performing clinical tests and the readiness of their results. The Nexus IB10 Analyzer is a compact, easy-to-use and fully automated POC system, utilising an immunochromatographic assay (ICA) method to measure and analyse results with a built-in sensor. Using whole blood or plasma samples, the test results are ready in up to 22 minutes and can be printed or sent directly to the laboratory information system (LIS). By simplifying the testing process, clinicians can focus on what matters most: Effective, quality patient care.

More details

POC diagnostics made easy

The sphingotest^®disc combines chemistry with centrifugal microfluidic flow to rapidly prepare cell-free plasma from whole blood, which can then flow through a channel to rehydrate, solubilise and mix with freeze-dried immunoconjugates. Using a combination of active flow and capillary action, the test is ready to be quantitatively measured within 22 minutes with an optical signal level proportional to the analyte concentration.

After adding the patient sample, the entire test is performed within the Nexus IB10 Analyzer, which controls everything from the temperature of the disc, the sequence, duration of measurement, centrifugal flow, mixing, incubation time, final signal measurement and quantitation right up to the reporting of results. The disc also includes a positive internal control to ensure that the test device has operated properly.

Each lot of discs is calibrated for the specific analytes to be measured to ensure that the lot-to-lot variability is minimised. Lot-specific calibration along with additional information such as the lot expiration date is contained on the QR code label affixed to each disc. It is recommended that quality controls also be run at appropriate time intervals to confirm that the reagent lot is performing within acceptable limits.

IB10 sphingotest^® product portfolio

Innovative acute and critical care biomarkers

SphingoTec develops and markets innovative in vitro diagnostic (IVD) tests for innovative biomarkers for the diagnosis, prognosis, and monitoring of acute medical conditions, such as septic shock and circulatory failure, acute heart failure, and acute kidney injury in order to support patient management and provide guidance for treatment strategies.

Item number	Test name	Parameters	Sample material
IVR-IB62	IB10 sphingotest^® penKid^®	proenkephalin A 119-159	EDTA whole blood / plasma
IVR-IB61	IB10 sphingotest^®bio-ADM^®	bioactive adrenomedullin 1-52	EDTA whole blood / plasma
IVR-IB58	IB10 sphingotest^® DPP3	dipeptidyl peptidase 3	EDTA whole blood / plasma

Standard-of-care biomarkers

Item number	Test name	Parameters	Sample material
IVR-IB65 *	IB10 sphingotest^® PCT	procalcitonin	EDTA whole blood / plasma
IVR-IB56 *	IB10 sphingotest^® NT-proBNP	NT-proBNP	Li-heparin or EDTA whole blood / plasma
IVR-IB52 *	IB10 sphingotest^® D-Dimer	D-dimer	Li-heparin or citrated whole blood / plasma
IVR-IB50 *	IB10 sphingotest^® Troponin-99	troponinI	Li-heparin whole blood / plasma
IVR-IB55 *	IB10 sphingotest^® TSH	TSH	Li-heparin whole blood / plasma
IVR-IB54 *	IB10 sphingotest^®beta-hCG	beta-hCG	Li-heparin whole blood / plasma
IVR-IB53 *	IB10 sphingotest^® Shortness of Breath	D-dimer, NT-proBNP, troponin I	Li-heparin whole blood / plasma
IVR-IB51	IB10 sphingotest^®3-in-1 Cardiac	troponin I, CK-MB, myoglobin	Li-heparin whole blood / plasma

* For these parameters, quality control materials in two levels are available.

Technical specifications

Key specifications [1]

Model name	Nexus IB10 Analyzer
Measurement principle	immunochromatography
Sample type	whole blood and plasma
Sample volume	500 µL
Time to result	up to 22 min [2]
Display	109 mm LCD touch screen
Maintenance	maintenance-free
Memory	5,000 results
Quality control	system performance: EQC – Electronic Qualification Control (IVR-IB60) test-specific internal QC: quality control material available in 2 levels
Printer	built-in thermal printer
Option	barcode reader
Connectivity	USB / PC, LIS, ASTM, HL7
Dimensions (W x H x D)	177 x 177 x 330 mm
Weight	2.4 kg