Sysmex Europe

OSNA in prostate cancer

Metastatic cancer spread to lymph nodes (LN) is a pivotal prognostic factor in prostate cancer, thus correct assessment of the nodal status is paramount for adjuvant treatment planning. In early stage prostate cancer, nodal staging is performed by pelvic lymph node dissection (PLND). This surgical procedure is associated with a high risk of post-surgical morbidities and considerable reduction of patients’ quality of life. Furthermore, metastatic LN involvement might be limited. Current histopathological assessment of dissected nodes comprises H&E staining of a few tissue sections often leaving small metastases undetected, thus impairing staging accuracy.

Alternative approaches to PLND aim to increase staging accuracy and reduce surgical radicality. One option is targeted PLND, where a selected number of lymph nodes is removed from ‘target’ areas of the pelvic lymphatic pattern/system. A second option is tracer-guided sentinel LND (sLND) to identify lymph nodes with the highest chance to harbour metastasis. Both methods aim to enhance staging accuracy by concentrating thorough LN analysis to a smaller number of nodes. However, histopathologic serial sectioning and immunochemistry are known to be labour-intensive and time-consuming and therefore not suitable for intraoperative use.

OSNA (one step nucleic acid amplification) constitutes an optimal solution to overcome such limitations. OSNA is a rapid, easy-to-use, highly sensitive and standardised molecular diagnostic which allows analysis of the entire LN, perfectly suited for the intraoperative setting. This enables clinicians to base treatment decisions on solid nodal staging information.

More details

Solution with OSNA

  • Sensitive, molecular whole node analysis avoids missing even the smallest metastasis and increases staging and prognosis accuracy.
  • Fast, fully informed intraoperative results allow to potentially reduce surgical radicality and related morbidities.
  • Reliable nodal staging supports adequate treatment choice and prevention of biomedical recurrence risk.

Sysmex Europe SE

Bornbarch 1

22848 Norderstedt


+49 (40) 527 26 0

+49 (40) 527 26 100


Product documents

Safety data sheets

  • Filter by language
  • Bulgarian
  • Croatian
  • Czech
  • Danish
  • Dutch
  • English
  • Estonian
  • Finnish
  • French
  • German
  • Greek
  • Hungarian
  • Italian
  • Latvian
  • Lithuanian
  • Macedonian
  • Norwegian
  • Polish
  • Portuguese
  • Romanian
  • Russian
  • Serbian
  • Slovak
  • Slovenian
  • Spanish
  • Swedish
  • Turkish
  • Ukrainian

Regulatory Documents

Regulatory documents, such as Instructions for Use, can be accessed with a valid My Sysmex login:

Go to My Sysmex

Explore more

Copyright © Sysmex Europe SE. All rights reserved.
Customize your experience

We use cookies to enable you to optimally use our Website and to improve our communication with you. We shall take your selection into account and use only the data for which you give us your consent.

* May lead to restrictions in content and in the user experience
Detail about cookies
Essential cookies
These cookies help to make our website usable by enabling basic features such as page navigation and access to secure areas of our website. Our website cannot function properly without these cookies.
Statistics cookies
By collecting information anonymously, these cookies help us to understand how visitors interact with our website. This information enables us to continually improve our platform.
Marketing cookies
are used to track visitors on websites. The intention is to show advertisements that are relevant and appealing to the individual user and are, therefore, valuable to publishers and third-party advertisers.