Revohem Anti-Xa LRT
Accurate anti-Xa measurement – all anticoagulants, one reagent
- Liquid, ready-to-use, Factor Xa (FXa) based chromogenic assay
- One universal solution; a single reagent to measure all anti-Xa anticoagulant activities in plasma:
- Heparins (UFH and LMWH)
- Danaparoid and fondaparinux
- Direct oral anti-Xa inhibitors (dedicated calibrators and controls for rivaroxaban, apixaban, edoxaban)
- Standardised, accurate, and easy-to-adapt without additional lab settings
- No antithrombin (AT) interference within the range of 50 -170%
- No PF4 interference up to 0.1 µg/mL
- Extended stability
Simple and efficient anticoagulant management one reagent for all anti-Xa drug activities
The RevohemTM Anti-Xa LRT method is a liquid, ready-to-use, one-stage chromogenic assay based on the inhibition of a constant, excessive amount of FXa in the presence of endogenous AT.
It is suitable for the quantification of indirect and direct anti-Xa inhibitors, such as heparins (UFH and LMWH) as well as heparin analogues (danaparoid and fondaparinux) and direct oral FXa inhibitors (rivaroxaban, apixaban, edoxaban) through dedicated, calibrators and controls aligned with WHO International Standards, ensuring high specificity and sensitivity. Furthermore, no interference from released heparin-neutralising proteins has been observed with the Revohem Anti-Xa LRT kit, due to the use of dextran sulfate.
Revohem Anti-Xa LRT and associated products are available on Sysmex’ CN- and CS-series.
Heparin anticoagulants (UFH and LMWH) are currently used for many preventive or curative indications. Heparin analogues (fondaparinux and danaparoid) are also used in specific clinical situations as alternative anticoagulant therapy, such as in the occurrence of heparin-induced thrombocytopenia (HIT). Measuring these drug concentrations in patient plasma allows for therapy monitoring and dose adjustments.
To monitor heparins and heparin analogues, an anti-Xa assay is the method of choice over the APTT due to its greater precision and rapidity. Additionally, it boasts more specificity and linearity over a wider measuring range, which reduces the amount of adjustments required during dosage.
Rivaroxaban, apixaban and edoxaban are direct oral anticoagulants (DOACs) that inhibit activated factor X (FXa). They have been increasingly used as first-line agents for eligible patients to prevent recurrent VTE and stroke in those with nonvalvular atrial fibrillation. Since their introduction into the market, the number of indications and direct oral factor Xa inhibitors have continued to grow. Due to their superior pharmacological and clinical profile, therapy monitoring is not required since frequent individual patient dosage adjustments are no longer necessary.
Though monitoring is not a necessity in treated patients, measurements of human plasma may still be required in certain cases, particularly in the event of emergency surgery, suspected overdosage due to renal impairment (bleeding risk) or suspected non-compliance (thrombosis risk).
Following the evolution of the anticoagulant market, the Sysmex portfolio expanded accordingly and will continue to grow alongside the market to ensure that we can always offer complete, universal solutions for laboratory measurement.
For further information, please refer to the dedicated Instructions for Use (IFU) or contact your local Sysmex representative.
Product name | LIQ | No standing time | Kit presentation | Order reference | |
Reagent | Revohem Anti-Xa LRT | ✔ | ✔ | 3 x 3 mL 4 x 5 mL 4 x 7.5 mL | CG217097 AL064127 BU634799 |
Diluent | Revohem Anti-Xa Diluent | ✔ | ✔ | 20 mL x 4 | AF018369 |
Heparins | Revohem Heparin Hybrid Calibrator | 5 levels x 4 x 1mL | BQ221064 | ||
Revohem LMWH Control Plasma | 2 levels x 6 x 1 mL | CE227688 | |||
Revohem UFH Control Plasma | 2 levels x 6 x 1 mL | AZ296682 | |||
Rivaroxaban | Revohem Rivaroxaban Calibrator | 3 levels x 3 x 1 mL | AC222492 | ||
Revohem Rivaroxaban Control | 2 levels x 6 x 1 mL | BB808578 | |||
Apixaban | Revohem Apixaban Calibrator | 3 levels x 3 x 1 mL | AP675507 | ||
Revohem Apixaban Control | 2 levels x 6 x 1 mL | AY519357 | |||
Edoxaban | Revohem Edoxaban Calibrator | 3 levels x 3 x 1 mL | CE077977 | ||
Revohem Edoxaban Control | 2 levels x 6 x 1 mL | AD713277 | |||
Fondaparinux | Revohem Fondaparinux Calibrator | 4 levels x 3 x 1 mL | CW731055 | ||
Revohem Fondaparinux Control | 2 levels x 6 x 1 mL | BT830756 | |||
Danaparoid | Revohem Danaparoid Calibrator | 3 levels x 3 x 1 mL | CE707939 | ||
Revohem Danaparoid Control | 2 levels x 6 x 1 mL | CJ744965 |
Heparin (UFH/LMWH) | Rivaroxaban | Apixaban | Edoxaban | Fondaparinux | Danaparoid | |
Measuring range | 0.05–1.80 IU/mL | 15–516 ng/mL | 20–601 ng/mL | 20–499 ng/mL | 0.05–1.68 µg/mL | 0.05–1.89 U/mL |
LoQ/LoD | 0.05/0.00 | 15/14.7 | 20/19.8 | 20/15 | 0.00/0.00 | 0.00/0.00 |
Precision | CV ≤10 % | |||||
Onboard stability on Sysmex analysers | 7 days | |||||
Interferences | Heparin (UFH/LMWH) | Rivaroxaban | Apixaban | Edoxaban | Fondaparinux | Danaparoid |
Haemoglobin | 300 mg/dL | 1000 mg/dL | 1000 mg/dL | 1000 mg/dL | 250 mg/dL | 300 mg/dL |
Bilirubin (free/Conjugated) | 25 mg/dL | 60 mg/dL | 60 mg/dL | 60 mg/dL | 45 mg/dL 30 mg/dL | 45 mg/dL 30 mg/dL |
Triglycerides | 875 mg/dL | 875 mg/dL | 875 mg/dL | 875 mg/dL | 1000 mg/dL | 315 mg/dL |
To find out more, please contact your local Sysmex representative.
All products listed on this webpage meet IVDR requirements and carry CE 0197 and UKCA conformity markings.
Latest update Dec. 2025
Sysmex Europe SE
Deelböge 19 D
22297 Hamburg
Germany
+49 (40) 527 26 0
+49 (40) 527 26 100
Revohem basic online training - Discover the basics of Revohem reagents and handling procedures on the CN-series in this online training and get started with Revohem products with confidence
For user trainings, please contact your local Sysmex representative.
