FIT screening

Colorectal cancer (CRC) is one of the most frequently diagnosed cancers. The good news is that CRC incidence and mortality can be reduced significantly if detected early enough.

Faecal immunochemical tests (FIT) are non-invasive and can detect blood in stool invisible to the naked eye. Due to its simplicity, FIT is currently considered the best non-invasive test for CRC screening.

Invest a little time in your own health by taking the FIT to prevent or detect colon cancer early on.
For further information, please visit our ‘FIT for screening’ website




Percentage of hypo-haemoglobinised red cells (HYPO-He) and hyper-haemoglobinised red cells (HYPER-He)

What are HYPO-He and HYPER-He used for?

Together with other parameters, HYPO-He is used in RBC indices to distinguish between iron defiency anaemia and thalassaemia.

The use of HYPO-He as well as MicroR is recommended in nephrology guidelines such as the European Best Practice Guidelines (EBPG), National Kidney Foundation Kidney Disease Outcome Quality Initiative (NKF KDOQI).

How are HYPO-He and HYPER-He determined?

HYPO-He and HYPER-He are parameters analysed in the reticulocyte (RET) channel. They are derived from the haemoglobin content of all mature RBC (RBC-He), which can be calculated based on the high-angle forward scatter (FSC). The FSC signal is converted into picograms (pg) using a proprietary algorithm and in healthy individuals the resulting RBC-He value is comparable to the mean corpuscular haemoglobin (MCH) value. Subsequently, this RBC-He value is used to determine HYPO-He and HYPER-He.

HYPO-He is the percentage of RBC with cellular haemoglobin content lower than 17 pg, whereas HYPER-He is the percentage of RBC with cellular haemoglobin content higher than 49 pg.

Figure: each cell is plotted in the RET scattergram based on its fluorescence intensity (x-axis) and its high-angle forward-scattered light signal (y-axis), which reflects characteristics of both cell size and cellular content. The left panel shows a sample from a healthy individual with HYPO-He less than 1% and the right panel shows a sample with HYPO-He more than 60%

HYPO-He and HYPER-He are diagnostic parameters on XN-Class analysers that have the RET channel. *


*In the XT-4000i and XE-5000 analysers these are research parameters that are derived from the RET channel and named %HYPO-He and %HYPER-He. Research parameters should not be used for in vitro diagnostics.

Immature Granulocytes

Immature Platelet Fraction
(IPF# and %)

Nucleated Red Blood Cells

Reticulocyte haemoglobin
equivalent (RET-He)

Neutrophil Granularity
and Reactivity

Microcytic and Macrocytic
Red Blood Cells
(MicroR, MacroR)

Reactive and Antibody-
synthesizing Lymphocytes

red blood cells (FRC*)

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White Blood Cells

Red Blood Cells

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